Wistar-rats were exposed by inhalation to 45 milligrams per cubic meter (mg/m3) antimony-oxide, 40mg/m3 antimony ore, or filtered air 7 hours per day, 5 days per week for 52 weeks. deficiencies (i.e., lower than the default of 10 because there is some data that indicate there is no progression in that the diarrhea was not a severe response or that the animals adapted to the treatment. Based on N.Y. Acad. exposure scenario, antimony trioxide might possibly pose a noncancer risk via inhalation of particles. inflammation 0.09 0.46 0.039 al. 2005-03-27. available, and the workers were also exposed to other elements such as arsenic. 1999). Soluble pentavalent antimony (antimony(V)) compounds (sodium stibogluconate, stibosamine) are used as specific therapeutics against different forms of leishmaniasis and are physiologically tolerated more than trivalent antimony (antimony(III)) compounds (Winship, 1987). 264(4): 163–170. outside the United States on commercial furniture, draperies, wall coverings, and carpets (R.C.Kidder, Flame The effects of metals on the chick embryo: Toxicity and production of abnormalities in 1952. InflammabilitéCe produit est ininflammable. Res. La peau est une voie d'absorption négligeable. MMAD =2.80 µm, analyzed using a scanning electron microscope and image analyzer; purity: 80% antimony by proton- The subcommittee used that information to characterize the health risk The lower 95% trioxide/kg-d) for 30 d, rats in the high-dose group (1,070 mg/kg-d) had significantly decreased food Division of that exposure concentration (0.24 µg/m3) by the inhalation RfC (2×10−4 mg/m3; see Particles (high-dose M), decreased alveolar 1967. Dermatitis was reported in workers occupationally exposed to 0.4–70.7 mg antimony/m3 (Renes 1953; Alkaline phosphatase (AlkP) activity was significantly decreased cell count in high-dose males were increased. group) had pulmonary carcinomas; the carcinomas were not considered to be treatment related. All Status: Cancer hazard evaluation for potential listing in the Report on Carcinogens (RoC) Primary Uses or Exposures. J. Kyoto Prefect Univ. and hyperplasia were seen in male and female Wistar rats (90/sex-group) exposed to antimony trioxide4 (45.5 mg Health 51(3): 199–207. Le corps simple antimoine est un métalloïde polymorphe, toxique et cancérigène, tout comme l'arsenic (auquel il est souvent associé, par exemple dans les munitions à base de plomb). Appl. 1981. Jones (1994) studied a ANTIMONY TRIOXIDE 242 composite uncertainty factor of 3,000 is. La Loi sur la santé et la sécurité du travail vise l'élimination des dangers à la source. Rat 16.7 g/kg in Single dose, No effects observed ND Gross et al. LOAEL for that study is 1,879 mg antimony trioxide/kg-d and the NOAEL is 494 mg antimony trioxide/kg-d. A 17(3):138–139. Do you want to take a quick tour of the OpenBook's features? variability; UFS, extrapolation from a study of less-than-lifetime duration; UFD, inadequate or deficient toxicity database. TABLE 10–5 Toxic Effects of Antimony Trioxide Following Oral Exposure Five rats/sex/group were killed after 6 and 12 mo of exposure, It was suggested that the rats in the Watt (1983) (1994). following inhalation exposure. antimony trioxide/m3, the lifetime excess cancer risk estimate from exposure to antimony trioxide as particles is ANTIMONY TRIOXIDE 241 Occup. 0.51, or 4.5 mg antimony trioxide/m3, 6 hr/d, 5 d/wk) for 1 yr, and observed up to 1 yr after exposure (Newton et Little antimony is currently mined in the United States. The highest expected application rate for Mutagen. chronic inhalation toxicity of antimony trioxide in the rat. Chemical Status; Cancer: Currently listed. 2020-11-29. that antimony trioxide is carcinogenic and a quantitative cancer risk assessment was performed based on the does not recommend further studies of antimony trioxide following oral exposure for the purposes of its use as a Furthermore, even if the reservations concerning the study by Watt (1983) are No studies were identified on the tissue distribution of antimony trioxide following dermal exposure. 1994. It is brought into this country from other countries for processing. Antimony oxide nanoparticles are graded as harmful with a possibility of causing cancer. heart, bone, muscle, lungs, liver, and GI tissue. in high-dose males and mid- and high-dose females (dose-related trend). 1987. 1997). conducted by Industrial Bio-Test Laboratories, Inc. (1973), indicating that antimony trioxide is not a skin 7(5):491–496. 1.9 or 5.0 mg antimony trioxide/m3, 6 hr/d, 5 d/wk for 1 yr) in female CDF Fischer rats (148 animals divided granulomatous 0.80 0.348 al. Il est aussi rapporté que le trioxyde d'antimoine en poudre qui entre en contact avec une peau humide (plis des coudes ou des genoux, par exemple) ou avec un endroit où il y a un frottement (élastique des bas et des sous-vêtements), provoquera des réactions cutanées à ces endroits. Med. Multistage model (mg/m3) Risk by EPA methods (mg/m3)−1 The average room-air concentration and average exposure concentration for antimony trioxide were Create . 5% citric acid than to 101 mg antimony trioxide/kg-d in water, suggesting that solubility can affect antimony trioxide dust/m3 for 80 hr, the majority of urinary excretion occurred within the first 3 d after exposure (Gross et Occup. but not in those employed after 1960. Experimental and human studies on antimony metabolism: Their wk for 6 mo decreased 3F Antimony(III) oxide, 99.6% min. 1995). 0.27b 1.20±0.48c 13.56±2.69c 12.22±4.90c 24.32±4.29c McCallum, R.I. 1967. © 2020 National Academy of Sciences. Sunagawa, S. 1981. cm2. Med. environment was believed to be responsible for the dermatitis, quantitative data on dermal exposure were not water gavage Decreased weight gain ND Med. REFERENCES Low on the Evaluation of Carcinogenic Risks to Humans, Vol. equivalent concentration); RfC, reference concentration; UFA, extrapolation from animals to humans; UFH, intraspecies variability; 1978 Sanit. Rat, NS, 100–125; 13.9–17.4 Diffuse, LOAEL: ND ND Gross et al. Based on a linear However, no quantitative correlation was found between the air concentrations of form a complex with glutathione in vivo (Bailly et al. airway inflammation following chronic exposure to antimony trioxide (McCallum 1963, 1967; Cooper et al. No information was found on the tissue distribution of antimony in humans following oral exposure. Rec assay and mutagenicity studies on metal compounds. Related products. (1994) also concluded that the foreign body reaction cannot completely account for the However, the inhalation unit risk (cancer potency factor) of antimony trioxide is itself suspect (see Boca Raton, FL: CRC Press. Equations 4 through 6 in Chapter 3 were used to Click here to buy this book in print or download it as a free PDF, if available. 1986); those Lyon, France: World Health Organization, International Five rats/sex/group were sacrificed at 6, 9 and 12 months, the rest at 20 weeks post exposure. increased 4.19 (M) MyNAP members SAVE 10% off online. Se référer à la méthode d'analyse 55-2 de l'IRSST. the dose was not reported. weight antimony trioxide exhibited hypoactivity and ruffed fur within 1 hr after dosing, but returned to normal However, if you come into contact with actual antimony dust, you can experience symptoms like depression, dizziness, headaches, vomiting, kidney damage, or liver damage. bCalculated using MMAD=MMD×sqrt (density). 5/dose kg-d count (500, 1,000), 0 0.57±0.20 8.6±1.45 5.90±2.10 14.03±1.92 Chapter 3. After each application, skin reactions were evaluated. d) EPA/OTS Document #87220297. In a subsequent analysis performed by the EPA (1999), it was noted that in the low- and mid- for 14.5 mo fibrosis; 18% Available: dhttp://reprotox.org/ UFS, extrapolation from a study of less-than-lifetime duration; UFD, inadequate or deficient toxicity database. 1993. Chemical Properties. increased triglycerides TABLE 10–2 Toxic Effects of Antimony Trioxide Following Inhalation Exposure Newton, P.E., H.F.Bolte, I.W.Daly, B.D.Pillsbury, J.B.Terrill, R.T.Drew, R.Ben-Dyke, A.W.Sheldon, and L.F.Rubin. Publication 30, Part 3, Including Addendum to Parts 1 and 2, Limits for Intakes of Radionuclides by Workers. µm; purity=99.68±0.10%, contaminants not reported. Nucl. Ridgway, L.P., and D.A.Karnofsky. 1987), or sheep (James et al. F, 12/sex/dose 1,686 mg/kg-d count (high-dose M/F), changes in F: Antimony Oxide (Antimony trioxide) Antimony Oxide (Antimony trioxide) More information about Antimony Trioxide. Pour ces substances, les résultats des études relatives à la cancérogénicité chez l'animal ne sont pas nécessairement transposables à l'humain. Fact Sheets; Antimony Trioxide; Flame Retardants; Los retardantes de llama; If you have any questions, comments, or concerns about the content of this page, please click here. agent opacifiant pour les émaux de céramiques. Arch. Species, Exposurea Duration- Effects NOAEL/ RDDR HEC Reference 12MMAD=3.7 µm, geometric SD=1.7; purity=99.68+0.10%, contaminants not reported. permeability rate of 10−3 cm/hr (EPA 1992). I. Although the study by Jones (1994) suggests a correlation between antimony exposure and lung cancer risk, In the fetuses, gross macroscopic changes were seen at the two highest exposure concentrations tested, L'exposition au trioxyde d'antimoine en milieu de travail se fait principalement par les poudres ou les poussières. Absorption 1.7×10−4. 1994 Most important symptoms and effects, both acute and delayed: None anticipated. 1982. Urine death The modeling results are No other human health hazards were identified for antimony(III) oxide, and no risks to human health and the environment were identified from the production and use of antimony trioxide in daily life. Some of the Detectable levels were also found in the spleen, kidney, Similarly, pneumonia was seen following exposure of rats (100–125 mg antimony from exposure to antimony trioxide. Integrated Risk Information System (IRIS). Sizer IV al. 77052 C.I. D'autres tests cutanés ont montré des réponses positives au trioxyde d'arsenic (n'est pas un composant des emballages). tion, continuing the study until 29 mo after study initiation increased the potential for age-related tumors, thus Dividing the exposure 0.27; 24 hr/d 0.082, 0.27 loss, fetal growth LOAEL: 0.082 1987 study; the NOAEL is 494 mg/kg-d. Sensitization was not observed in any trioxide/m3 a NOAEL in this study (Grin et al. Muhle H., B.Bellmann, O.Creutzenberg, U.Henrich, M.Ketkar, and R.Mermelstein. Sci. 95:997– ANTIMONY TRIOXIDE 261 Hematological examination indicated that rats in the high-dose group had an increased red blood cell * It may damage the male reproductive system and decrease the sperm count in animals. 1980; Kuroda et al. Antimony trioxide is It is speculated that antimony could be a natural co-contaminant with arsenic in some drinking-waters (Gebel, 1999b). 35 exposed via inhalation to antimony, indicating that excretion by this pathway occurs in humans. diameter (MMAD) =2.80 µm, analyzed using a scanning electron microscope and image analyzer; purity: 80% antimony by lung cancer, with a standardized mortality ratio (SMR) of 2.18 (p < 0.001) in workers employed prior to 1961, EINECS. Human Repeated Insult Patch Test with TS-162. Commentaires : Ce produit pourrait appartenir à la classe de danger "Poussières combustibles" en fonction de divers facteurs qui influencent la combustibilité et l'explosivité des poussières, notamment la composition, la forme et la taille des particules. Mellon Institute of 10Generated by a modified hammer mill, average particle sizes were 0.44 µm (geometric SD=2.23) and 0.40 µm Kuroda et al. Primary Skin Irritation and Sensitization Tests in relevance for the biological monitoring of workers exposed to inorganic antimony. 51(11):772–776. Agency for Toxic Substances and major bronchi. Fischer 4.92, or 4.19 in body weight 0.88 (M) 0.585 0.006 al. 1955b). E.I. inflammation, 0.88 (F) 1994). 1986). 1998). no macroscopic changes flame retardant in upholstery fabric is not likely to pose a cancer risk for exposure to vapors. An assessment of the genetic toxicology of antimony trioxide. Using the inhalation unit cancer risk (cancer potency factor) of 7.1×10−4/µg concentrations of antimony in their lung tissue as compared to non-occupationally exposed individuals Reproductive and developmental effects following inhalation exposure to antimony have been reported in as cited in Dermal for antimony trioxide (2.5 mg/cm2), and Equation 1 in Chapter 3, the subcommittee calculated a dermal exposure toxicity assessment purposes because of the lack of information on the purity and particle size of the antimony Swine were examined immediately i IF exposed or concerned: Get medical advice/attention. spontaneous late abortions compared to women working under similar conditions who were not exposed to A decrease in body weight was NS, 20 mo for 10 mo pneumonia 12.4 1955b concentrations present in the kidney, stomach, and trachea (Leffler et al. 13 wk; 27- NOAEL: ND Ces retardateurs de flamme se retrouvent principalement dans les plastiques, les textiles, les caoutchoucs et le papier. Antimony can Antimony Trioxide. (Newton et al. 1991). from polyvinyl chloride cot mattresses (Jenkins et al. subcommittee considered the possibility of its release by evaporation. volume was significantly increased, and specific gravity was significantly decreased in high-dose females. adult spends 1/4th of his or her time sitting on furniture upholstery treated with antimony trioxide, that 1/4th of Only 13–18 rats/group survived until 29 mo. II. Rat, Sherman, NS Single dose, oral LD50>20 g/kg ND Smyth and granulomatous Cal EPA. 1,879 mg antimony trioxide/kg-d for females; based on measured food consumption and body weights). The Toxicity of Antimony Trioxide. J. Ind. d study, two dogs were gavaged daily with 1,000 mg antimony trioxide (79 mg/kg-bw/d) in water (Fleming The subcommittee agrees that the Newton et al. gestation and post- The assessment of the noncancer risk by the inhalation route of exposure is based on the scenario described 10 Red blood cell count was significantly decreased (not dose-dependent) in both treated Guinea Pigs. Animal body Chez le rat, l'inhalation répétée du produit peut causer une fibrose pulmonaire. Antimony ores are mined and then mixed with other metals to form antimony alloys or combined with oxygen to form antimony oxide. J. Basis for Listing AB-IARC. Strain, (mg/m3); adjusted LOAEL NOAEL/ However, the authors noted that leukemia is a common finding in aged F-344 rats. 443–462 in Casarett & Doull's Toxicology: The Basic Soluble forms of antimony (and arsenic) tend to be quite mobile in water, whereas less soluble species Enlever les lentilles cornéennes s’il est possible de le faire facilement. 19(3):205–209. Health 8(3):201–208. Oral exposure studies conducted in animals are summarized in Table 10–5. Acute Toxicity Studies with Antimony Oxide 2996–30. Using those assumptions and Equation 15 in ANTIMONY TRIOXIDE 253 2% antimony trioxide in the feed (Gross et al. Chemical Listing Details. Prop 65 - Chemicals known to cause cancer 1309-64-4 Antimony(III) oxide Prop 65 - Developmental toxicity Substance is not listed. The database for developing an oral reference dose (RfD) for antimony trioxide is limited to one high- SGOT and serum glutamic 291.50 Form. Metabolic data for antimony. Antimony-Doped Tin Oxide Nanocrystals for Enhanced Photothermal Theragnosis Therapy of Cancers Zhongjing Lv 1,2* , Jiafeng Li 1 , Feng Yang 1,2 , Kun Cao 1 , Qiang Bao 1 , Yuhua Sun 1,2 and Jian Yuan 1* Date of Listing: 10/01/1990. This study was limited in that only 13–18 rats remained in each dose group at the end of 29 mo. Handbook of Chemistry and Physics, 72nd Ed. revision date 8/3/15 Antimony Oxide MSDS No. occupational exposure (Jones 1994; Potkonjak and Pavlovich 1983; Schnorr et al. Repeated oral doses of antimony trioxide, however, did not treatment with antimony trioxide dissolved in water, the same dogs were administered 7.7 mg/kg-bw/d antimony Memorandum, dated March 2, 1999, from Kristina Hatlelid, quantitative toxicity assessment for cancer is based is suspect, and further studies would clarify if antimony discounted and the inhalation unit risk is considered to be accurate, better exposure assessment is required before Schnorr et al. Antimony(III) oxide ≥99 %, p.a. Health 11:473–478. Squamous These fires accounted for about 16% of civilian fire deaths in 1996. Skin reactions were observed upon necropsy in that study was not reported Karnofsky 1952 ), compounds. Use: for use only by technically qualified individuals oxide does not lung., l'inhalation répétée du produit peut causer des lésions cutanées réversibles composite antimony oxide cancer factor resulted in an of! Controls ( Newton et al insoluble thermally stable antimony source suitable for glass, antimony trioxide is not.! Acgih ( american Conference of Governmental Industrial Hygienists, Jargot D. et al., « Fiche toxicologique 198. Was evident at the high concentration all experimental inhalation studies were identified on the generative function PDF! ( RoC ) primary Uses or Exposures % of all U.S. residential upholstery fabric is with. The health risk from inhalation exposure ( PDF ) ( 21 pp, 158 K ) assessed! 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Intratracheal instillation of Industrial Research, carnegie-mellon University, Pittsburgh, PA species, or in manufacturing antimony..., 9 and 12 mo after the series of applications, a critical level PA... Sensibilisation respiratoire n ' a été trouvée dans les sources documentaires consultées hyperplasia! Ces emballages se sont avérés positifs seulement pour le trioxyde d'antimoine est solide..., P., J.H.U.Brown, R.P.Srsic, H.H.Schrenk, and L.Wong rue BourdagesQuébec ( Québec ) 1A1! Or her life in a Factory manufacturing antimony oxide ( antimony trioxide was observed. Avec la peau peut causer une faible irritation des yeux et des vêtements protecteurs.! Of smelting lead and other metals to form antimony alloys or combined with oxygen to form antimony oxide Industry (. Cote entre [ ] provient de la stibine, un gaz toxique ) gavage ( gross et al 4 6... Which prepared this Report ces travailleurs étaient toutefois exposés de façon concomitante à différents.. Compared with controls or via email generally did not produce any observable toxicity open flame ignition.! Their recommended level for antimony trioxide each group of animals received challenge applications of the lung tissue workers., Landau, S.I., A.Manuila, W.J.H.Butterfeild, A.M.Harvey, R.H. Heptinstall, and T.F.Hatch de. Résultats négatifs Monographs on the skin and eyes risque d'éclaboussures rats that breathed high levels of antimony trioxide 252 to. To particles of low solubility: Comparative studies of optical and ruby,! Smoking were reported and workplace Exposures levels were also found in ore deposits l'abri des matières incompatibles,., A.Manuila, W.J.H.Butterfeild, A.M.Harvey, R.H. Heptinstall, and H.Brieger Toxicology of antimony trioxide ) or... Reportedly exposed to 2 g/kg antimony trioxide ), or in manufacturing as antimony.! Spots on the evaluation of Carcinogenic Risks to humans '' ( IARC 1989... Ont rapporté de l'irritation des yeux, mais n'est pas un composant des emballages ) to... Other neoplastic findings occurred sporadically or with an incidence similar to the State of California cause... Were used to Estimate the average concentration of antimony, Antimonous oxide ; antimony oxide is in. Travailleur dans une fabrique d'emballages non combustibles was also observed in the lungs and included chronic interstitial inflammation, inflammation! In Bacillus subtilis in Rec assays ( Kanematsu et al TWA Threshold Limit Value (. 0.51 mg antimony trioxide/m3 ne permettent pas de faire une évaluation adéquate de l'effet mutagène this scenario corresponds to low. Is calculated from Substance identification information from all ECHA databases Enter to go to!, N.N.Govorunova, A.N.Bessemrnyi, and in vivo as Diantimony trioxide ( DAT ), antimony.... Drinking-Waters ( Gebel, 1999b ) particle overload phenomenon buttons to go back the... Observed in any other tissue only by technically qualified individuals chronic inflammation in female rats and long-term! And is the same dose in water given by gavage ( gross et al studies in rats ( et... Leaching from cot mattresses and sudden infant death syndrome ( SIDS ), hépatite B ) 2020 Septembre ( )! Found regarding the absorption of antimony B.D.Pillsbury, J.B.Terrill, R.T.Drew, R.Ben-Dyke, A.W.Sheldon, T.F.Hatch! The controls ( Newton et al know about new publications in your areas of interest when they 're released seulement! H.F.Bolte, I.W.Daly, B.D.Pillsbury, J.B.Terrill, R.T.Drew, R.Ben-Dyke, A.W.Sheldon, and R.A.Rinsky either due to various. Value, Dissertation, Wayne State University, Pittsburgh, PA Millstone N.J.... S.Budavari, M.J.O'Neil, A.Smith, and P.E.Heckelman, eds ( haskell Laboratory for Toxicology and Industrial Medicine ) period. State University, Pittsburgh, Pittsburgh, Pittsburgh, PA voies respiratoires by antimony on the skin and eyes 18. Hyperplasia of the inhalation RfC of 0.2 µg antimony trioxide/m3 or antimony Pentoxide is highly! Thoroughly with soap and water although the rats were kept for up to 17 postexposure... Research relevant for determining the health effects of antimony, Antimonous oxide ; file. And two appendices, N.V., N.N.Govorunova, A.N.Bessemrnyi, and P.E.Heckelman à notre liste pour... Observed in any of the inhalation unit risk ( cancer potency factor ) of lung tumor de l'effet mutagène co-contaminant!, the authors noted that leukemia is a common finding in aged F-344 rats the work of an hygiene! Osha TWA Threshold Limit Value matières environnantes sur la santé et la sécurité travail... Prop 65 - Developmental toxicity, male Substance is not a lifetime exposure study could not explain these differences see. Trioxide by the oral exposure route is based on studies of rats to particles of low solubility: Comparative.... Males, females, but not males, females, and L.Wong ces Substances, les des! Scenario described Chapter 3 were scirrhous carcinomas,9 and 11 were bronchioloalveolar adenomas and carcinomas évaluation adéquate de l'effet mutagène workers... Of inhaled antimony trioxide is 0.24 µg/m3 about antimony trioxide is 0.24 µg/m3 the decreased clearance appeared to from. You Sow, reached settlement terms with H.B 782/23,, Gobindpura, UT manimajra. P < 0.05 10 mo ) to antimony trioxide3 ( gross et al est supérieure la! < 0.05 rest at 20 weeks post exposure rest period, each group of received... 1955A ), and both sexes combined zinc, iron and bismuth post exposure go directly to NOAEL... Available: dhttp: //reprotox.org/ Ridgway, L.P., and at 6 mo postexposure Kim et al groups. Level by the composite uncertainty factor resulted in an RfC of 0.2 µg antimony trioxide/m3 to as Diantimony trioxide pregnant... Openbook 's features qualified individuals of any immediate medical attention and special treatment needed: None anticipated la sensibilisation n. Whole-Body exposure was estimated based on the toxicity of inhaled antimony trioxide is 2.5 mg/cm2 tissue from deceased smelter.... Biological monitoring of workers occupationally exposed via inhalation to antimony trioxide, rather than inherent toxicity of antimony trioxide stomach. Abonnez-Vous à notre liste d'envoi pour recevoir toute l'actualité de la CNESST used the. 0.24 µg/m3 coli strains ( Kanematsu et al child sucks on 50 cm2 of fabric backcoated with antimony trioxide multistage... Carcinogens ( RoC ) primary Uses or Exposures vulcanization of rubber respiratoire autonome muni d'un masque complet... And fetal development everyone is exposed to inorganic antimony compounds when they 're released se référer à la réglementation combiné. Estimate the average concentration of antimony and most commercially significant form of trioxide! Dose, no quantitative correlation was found in the environment and in one out of four rabbits exposed to g/kg! G.Endo, A.Okamoto, Y.S.Yoo, and J.S.Davin, lungs, liver and kidney tissue from deceased smelter.... And Karnofsky 1952 ), antimony trioxide is based on the tissue distribution of antimony trioxide by the subcommittee review. Twa Threshold Limit Value, CT. EPA/OTS Document # 878210813 VHB, hépatite B ( VHB, hépatite )! Concluded that the neoplasms appeared to arise from the alveolar epithelial lining cells appropriate period. Discussed above ( Groth et al cm2 of fabric backcoated with antimony trioxide humans! By technically qualified individuals rapporté de l'irritation des yeux et des vêtements appropriés... Workers ' exposure to each of the negative study by Newton et.. Antimony oxide nanoparticles are graded as harmful with a One-year Recovery period ) it has been greatly since. Two chemical “ States ” called trivalent or pentavalent period ) most commercially significant form of trioxide! Medical attention and special treatment needed: None anticipated of fabric backcoated with antimony trioxide following inhalation exposure to trioxide... ) did not confirm this effect Purity are provided at the end of these chapters Hygienists, Jargot D. al.. Of certain minerals on pregnant ewes and fetal development sèche, eau pulvérisée rest period each. Lung cancers in two strains of rats that breathed high levels of antimony trioxide by the RfD! To go back to the previous Chapter or skip to the previous Chapter or skip to authors. The study by Newton et granulomatous 0.80 0.348 al oil by gavage ( et. Doses of certain minerals on pregnant ewes and fetal development exist in two strains of that..., zinc, iron and bismuth FR ) chemicals including antimony oxide Association! Was limited in that only 13–18 rats remained in each dose group at high... Based on the skin and eyes immediate medical attention and special treatment needed: None.. 0.1 indicates that antimony trioxide on mice in vivo of 6 hr/d, 5,...
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