+3. There are more than 8,000 villages in Bangladesh where more than 80 percent tube-wells are arsenic It acts on glycolysis, TCA cycle and on Pyruvate dehydrogenase complex. Toxicology Letters 133:1-16 Jomova, K., Jenisova, Z., Feszterova, M., Baros, S., Liska, J., Hudecova, D., Rhodes, C.J., Valko, M. (2010). arsenic is a solid, liquid , and a gas!. Stools were initially Rice water type but later became bloody
On examination he had some nail changes, sensory loss and dermatitis like picture. Request PDF | On Jan 1, 2000, D. N. Guha Mazumder published Chapter 4 : Diagnosis and treatment of chronic arsenic poisoning | Find, read and cite all the research you need on ResearchGate Guide to Nutritional Supplements. Arsenic Poisoning - Free download as Powerpoint Presentation (.ppt / .pptx), PDF File (.pdf), Text File (.txt) or view presentation slides online. Arsenic is a natural component of the earth’s crust and is widely distributed throughout the environment in the air, water and land. and signs of arsenic poisoning in human beings may increase with a de crease in arsenic level in the drinking water source. PHM142H1-F October 9, 2013. as atomic number: 33 relative mass: 74.92 metalloid grey or yellow or black, Poisoning - . Lead (Pb) has been used by humans for at least 7000 years, because it is widespread, easy to extract, and easy to work with. EvironmnetalChemistry.com. PHM142H1-F October 9, 2013. http://dx.doi.org/10.1155/2013/219840 Sullivan, John B. and Gary R. Krieger. not anticipated! 33. Arsenic, element 33, has a long and nefarious history; its very name has become synonymous with poison. Arsenic Detection Techniques - . It is highly toxic in its inorganic form.People are exposed to elevated levels of inorganic arsenic through drinking contaminated water, using contaminated water in food preparation and irrigation of food crops, industrial processes, eating contaminated food and smoking tobacco.Long-term exposure to inor… Now customize the name of a clipboard to store your clips. Arsenic poisoning acts on different metabolic pathways of glucose metabolism. Acute Poisoning: Symptoms of acute intoxication usually occur within 30 minutes of ingestion but may be delayed if arsenic is taken with the food. APIdays Paris 2019 - Innovation @ scale, APIs as Digital Factories' New Machi... No public clipboards found for this slide. atomic number is 33 atomic mass is 75 family: 15 nitrogen. A patient was bought to the Emergency ward with history of rashes and blebs all over his skin mainly on his arms and feet. If you continue browsing the site, you agree to the use of cookies on this website. PHM142 Fall 2013 Instructor: Dr. Jeffrey Henderson. Furthermore, it was observed that new cases of human poisoning … arsenic. Arsenic toxicity and potential mechanisms of action. Patient went into shock and finally was admitted in the ICU
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. Welcome to Click to edit Master subtitle style ARSENIC POISONING Click to edit Master subtitle style Amir Sadaula (01) Arjun Pandit (02) Bikas Puri (03) Bishwo Bandhu Pokharel (04) by: marquise washington. Absorption • Soluble and acidic arsenic compounds are readily absorbed in the stomach • Inorganic Arsenic compounds can also be sequestered on mucosal linings, leading to irritations and a concentration gradient that aids in the absorption of Arsenic compounds. Symptoms of arsenic poisoning, or arsenicosis, can include skin lesions, swollen limbs and loss of feeling in the hands and legs. o vervie w. efficiency chemical structures uses problems, Poisoning - . Arsenic poisoning 1. This a special article from Telugudoctors.co.in; Hope you find it useful and informative. • Carcinogenic due to oxidative stress, inhibition of p53, genotoxicity, altered DNA repair mechanisms and tumor promotion • “Arsenite” - Trivalent (As3+): Reacts with reacts with thiols and sulfhydryl groups • Inhibits GSH Reductaseblocks of GSH production Oxidative stress and production of free radicals • Inhibits Pyruvate Dehydroxygenase decreased activity in Citric Acid Cycle decreased ATP production and Gluconeogenesis • “Arsenate” - Pentavalent (As5+): replaces phosphate groups because of similar molecular structure). two kinds of poisoning have been identified by the national safety, Poisoning - . A 43-year-old male attempted suicide in July, 2001, by drinking 54 g of arsenic trioxide (As2O3). poisoning. If arsenic poisoning occurs over a brief period of time, symptoms may include vomiting, abdominal pain, encephalopathy, and watery diarrhea that contains blood. Summary Exposure to heavy metals such as mercury, lead, iron, and arsenic is harmful to the human body and can potentially cause both acute symptoms (e.g., local irritation, gastroenteritis, and pneumonia) and longterm effects (e.g., abnormal physical development, cancer, damage to the central nervous system, and kidney). Long-term exposure to arsenic can also lead to cancer, possibly affecting the lungs, bladder and Retrieved from Lecture Notes Online Website: http://mstc.csmu.edu.tw/ezcatfiles/mstc/img/img/466/961008-BarryPhilipRosen.pdf Sears, M. E. (2013). Arsenic PowerPoint Presentations you can use in your safety training programs. • Recommended treatment is Dimercaptosuccinic acid (DMSA). Arsenic Poisoning. Features of the initial clinical presentation included nausea, vomiting, and diarrhea, acute psychosis, diffuse skin rash, and marked pancytopenia. why is it called arsenic?. dr esther tsang august 2011. case 1. 135 xe 10 6 b. (2011). elment info. Print. A patient was bought to the Emergency ward with history of rashes and blebs all over his skin mainly on his arms and feet. Arsenic as a Global Pollutant - Arsenic as a Global Pollutant Tiffany Berg March 26th, 2011 Health effects of arsenic poisoning Keratosis Internal tumors Cancers of the skin, liver, bladder, and lungs. © 2020 SlideServe | Powered By DigitalOfficePro, - - - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - - -. Toronto: Oxford UP, 2009. He also used to complain of tingling and numbness over his hands and foot.
He gives history of having consumed water from his work place for the past 3 days as he forgot to carry his own bottle and has been suffering from severe gastroenteritis ever since. properties. Slide 7- ppt slide no 7 content not found What causes chronic arsenic poisoning? ryan clark & candace williams. as. Arsenic - . Arsenic poisoning is a medical condition that occurs due to elevated levels of arsenic in the body. Arsenic Trade Show Treatment Options Overview The main considerations when selecting a treatment technology include: Water quality characteristics (including pH levels and initial concentrations of iron, As(III), and As arsenic compliance in perspective water, Arsenic - . poisoning. ARSENIC POISONING A. Metabolism • Main organ for arsenic metabolism is the liver, Metabolism continued Step 1 • Inorganic pentavalent arsenate is reduced to trivalent arsenite in the blood stream before entering the cells • Can occur non-enzymatically in the presence of a thiol such as glutathione (GSH), Metabolism continued Step 2 • Methylation to monomethylarsonic acid (MMA) and to dimethyl- arsinic acid (DMA) is enzymatic, requiring S- adenosylmethionine (SAM) and a methyltransferase • MMA and DMA are excreted in the urine (thousandfold less-potent as mutagenic agents than inorganic arsenic) • Methylation has long been considered the main route of detoxification, but there is growing literature supporting other methods such as transport and antioxidant defenses, Mechanism of Action of (As3+) • Reacts with thiol-containing molecules (R-SH) • Arsenite inhibits GSH Reductase by interacting with critical thiol groups • Blocks production of GSH (glutathione, important antioxidant) causing increased free radicals and oxidative damage • Increased production of ROS such as superoxide radical, singlet Oxygen, hydroxyl radicals, hydrogen peroxide, Mechanism of Action of (As3+) • Inhibits lipoicacid (a dithiol) which is an important cofactor for Pyruvate Dehydroxygenase (PDH) • As [Acetyl CoA] decreases  Citric Acid Cycle activity decrease, causing: • Decreased ATP production • Decreased Gluconeogenesis (synthesis of glucose from carbohydrates, fatty acids, proteins, etc) Function of PyruvateDehydroxygenase: Oxidize Pyruvate to Acetyl CoA before Citric Acid Cycle Arsenic binds to Lipoid Acid-PDH to form 6-member ring Lipoic Acid-PDH, Arsenate resembles Inorganic Phosphate Competitively inhibits phosphate for active site in G3P-Dehydroxygenase Replaces phosphate in many biochemical reactions in cellular respiration ATP ADP-arsenate (arsenolytic mechanism – uncouples ATP formation) Glucose-6-Phosphate  Glucose-6-Arsenate Glyceraldehyde-3-Phosphate  Glyceraldehyde-3-Arsenate Mechanism of Action of (As5+) Inorganic Phosphate is chemically similar to Inorganic Arsenate, Inhibition of Glyceraldehyde-3-Phosphate dehydrogenase, Arsenic is a Carcinogen • Associated with oxidative stress, cell arrest in the G2/M phase, chromosomal abnormalities, and DNA aneuploidy. Mandal, B. K., & Suzuki, K. T. (2002). On arrival he was pale and diaphoretic, but his vital signs were normal. Journal of Applied Toxicology. | PowerPoint PPT Arsenic - . seafood –, Poisoning - . (2002). • Inhibits p53, Treatment of Arsenic Poisoning • Chelation therapy removes heavy metals • Dimercaprol • First antidote • Intramuscular Injection (painful) • Narrow therapeutic window • DMSA • Currently used • Fewer side effects • Can be administered orally Dimercaprol Dimercaptosuccinic acid (DMSA) Dimercaptosuccinic acid (DMSA), Summary • Symptoms include headache, drowsiness, diarrhea, vomiting, bloody urine, convulsions, changes in fingernail pigmentation • Enters body via inhalation and/or ingestion and mainly distributes to liver • Inorganic arsenate is metabolized in liver by methylation to MMA and DMA. Retrieved from http://library.concordia.ca/help/howto/apa.php#online Hughes,M, F. Beck, B,D et al. See our User Agreement and Privacy Policy. Those who survive arsenic trioxide poisoning may develop encephalopathy or severe peripheral neuropathies. The three main sources of exposure are occupational exposure, natural contaminants of drinking water (from some deep water wells) and ancient Chinese medicinal remedies containing arsenic. References Caballero, B.(2009). Cancer Research. -3. poisoning. SOS-Arsenic: Private Iniciative against Poisoning of Ground Water in Bangladesh The arsenic hazard in Bangladesh villagers now appeared as a ‘real disaster', affecting thousands physically, physiologically, mentally and economically; it is intensifying malnutrition, … However, symptoms of chronic arsenic poisoning from ingestion of contaminated water are typically observed only after 10 or more years of exposure. 33 2,8,18,5 as arsenic 74.92160. electron diagram. Wayne State University School of Medicine [PDF Document]. As 33 74.99. claire m. waggoner aquatic toxicology. jonathan kernaghan. arsenic poisoning in tube. time scale: hours and days. Arsenic. Mechanism of arsenic poisoning Adrian Bumstead, Xiao Qi Li, Jessica So, Jin (Donna) Yang PHM142 Fall 2015 Instructor: Dr. Jeffrey Henderson Overall - try to keep the text to a minimum (the presentation guideline for the cardio Create stunning presentation online in just 3 steps. by, jeremy rubert. His blood picture and abdomen radiography were as in the images. Looks like you’ve clipped this slide to already. Presented by: Nirojan Balachandran Saranga Sreeskantharajan Kimberly Stobo Tian Qi Wang. 62:3893-3903 Mcintyre, D, O. Linton, T, K. (2011). albertus magnus (1193-1280), a german philosopher and theologian, was the first to state that arsenic has a, Arsenic - . reactor shut down!. Your advice would be useful in perfecting our future slides. substance which when introduced into body in relatively small amounts causes in structural damage, Arsenic Rule - . this element's name was derived from " arsenikon. structures, physical and chemical properties, Poisoning - . arsenic - . prepared by muhammad hashim. 6 th period by: katelyn keller brianna leslie tiffany goulart. 25 year old vietnamese lady unable to communicate due to language, Arsenic Poisoning in tube wells in bangladesh - By: lauren jones & david pinigis. Arsenic poisoning, or arsenicosis, happens when a person takes in dangerous levels of arsenic. You can change your ad preferences anytime. properties. Presented by: Nirojan Balachandran Saranga Sreeskantharajan Kimberly Stobo Tian Qi Wang. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. +5. Diagnosis of arsenic poisoning is made by determining inorganic and organic levels of arsenic in the blood and urine. It is a high-profile problem due to the use of deep tube wells for water supply in the Ganges Delta , causing serious arsenic poisoning to large numbers of people. Johnston and Heijnen : Safe Water Technology for Arsenic Removal 3 should be considered, so that the workload of women and girls is not unduly increased. Talanta, 58, 201-235. http://dx.doi.org/10.1016/S0039-9140(02)00268-0 Miller, W., Schipper, H., Lee, S., et al. A brief presentation on Arsenic poisoning encompassing 40 slides - also included is a quiz on toxicology at the end. China lead poisoning(2009) Zamfara lead poisoning(Mar-June 2010): About 163 deaths due to illegal extraction of ore by villagers in Anka & Bukuyyum LGA’s. Physical Properties. atomic number:33 element symbol:as element name:arsenic atomic mass:75. Clinical Environmental Health and Toxic Exposures, Lippincott Williams & Wilkins; 2 edition (June 4 2001). chronic arsenic poisoning among workers (17). the poison of kings. Arsenic is a natural semi-metallic chemical that is found all over the world in groundwater. Dr Kaleem Khan Assistant Professor JNMCH 2. Arsenic - . PHM142 Fall 2013 Instructor: Dr. Jeffrey Henderson. Chelation: Harnessing and Enhancing Heavy Metal Detoxification- a review. See our Privacy Policy and User Agreement for details. It is the common environmental toxicant and is found in soil, water, and air. small systems implementation strategy & exemptions. 2,8,18,5. information. Treatment of arsenic poisoning in acute toxic poisonings needs to begin quickly; treatment involves removal of arsenic by dialysis , chelating agents, replacement of red blood cells , and if ingested, bowel cleansing. Customer Code: Creating a Company Customers Love, Be A Great Product Leader (Amplify, Oct 2019), Trillion Dollar Coach Book (Bill Campbell). 33. as arsenic 75. arsenic. p.861-864. arsenic. Arsenic - . If you continue browsing the site, you agree to the use of cookies on this website. Poisoning - By kristin hoffpauer , courtney maccallum , sarah plante , sammi pedigo. used : rat poison found: food, water. peter worcester a period. Arsenic poisoning( acute, subacute and chronic) 1. • Metabolized to toxic form of As3+ , MMA(III) before entering cells • ADP forms ADP-arsenate instead of ATP; Glucose-6-Arsenate instead of G6P; Glyceraldehyde-3-arsenate instead of G3P. The Scientific World Journal, 2013, 13 Pages. Arsenic has been used since 3000 BC. Arsenic - Laura stanton. food air water. 1. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. poisons. Get powerful tools for managing your contents. Long-term Clipping is a handy way to collect important slides you want to go back to later. We have tried to make it as attractive, brief and informative as possible. • Arsenic depositions in the brain and spinal cord can lead to developmental disabilities, and cognitive impairments. He was admitted 5 h later. Contamination is caused by arsenic from natural geological sources leaching into aquifers, contaminating drinking water and may also occur from mining and other industrial processes. Mechanisms of Action of Arsenic Trioxide. The patient, a chemist by profession, prepared this amount of arsenic trioxide in his factory laboratory using a commercial solution of arsenic trichloride (AsCl3) as a base. , element 33, has a, arsenic - glycolysis, TCA cycle and on Pyruvate dehydrogenase.. Long and nefarious history ; its very name has become synonymous with poison, adverse effects within... 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